Polycystic kidney disease (PKD) is a hereditary condition that affects a variety of mammals, including humans and felines. Feline polycystic kidney disease (FPKD) has become one of the most common feline genetic diseases, with higher rates of diagnoses being seen among certain breeds, such as the Persian cat. The significant sign of this disease is the formation and growth of fluid-filled cysts on the kidney and can include other organs, such as the liver or pancreas. Without awareness and rigorous tracking of genetic carriers, cats will continue to be born with and succumb to FPKD, eventually resulting in kidney failure. Additionally, cats with FPKD are theorized to be ideal models for human PKD. Therefore, by understanding the feline condition, it is hoped that human PKD research can also progress (Lyons, L., et al. 2004.). There is currently no cure for this disease; however, dietary and lifestyle changes are used to increase quality of life and comfort. Understanding this disease and its mechanisms is crucial to decreasing the number of affected felines (Schirrer, L., et al. 2021.).